Wound, Ostomy and Continence Nurses Society (WOCN) Practice Exam

In the proliferative phase of full thickness wound repair, what two processes are primarily involved?

1. Hemostasis and granulation tissue formation

2. Epithelialization and granulation tissue formation

3. Infection control and necrotic tissue removal

4. Regeneration of nerve endings and muscle fibers

The correct answer is: Epithelialization and granulation tissue formation

During the proliferative phase of full thickness wound repair, the primary processes involved are epithelialization and granulation tissue formation. Epithelialization refers to the re-establishment of the epidermis over the wound surface. This process is crucial as it provides a barrier against pathogens and helps to restore the skin's protective functionality. Granulation tissue formation involves the development of new connective tissue and blood vessels, which is vital for wound healing as it supplies nutrients and oxygen to the area, thereby facilitating further healing processes. Both epithelialization and granulation tissue formation work together during this phase to lead the wound toward closure, ensuring that the wound heals effectively and efficiently. The formation of granulation tissue creates a scaffold for epithelial cells to migrate across, promoting healing. This collaborative interaction is central to restoring the integrity of the skin and underlying tissues after a full thickness wound.