Wound, Ostomy and Continence Nurses Society (WOCN) Practice Exam

Which of the following is not a typical sign of corticosteroid effects on wound healing?

1. Increased collagen synthesis

2. Delayed epithelialization

3. Reduced inflammation

4. Impaired wound contraction

The correct answer is: Increased collagen synthesis

In the context of corticosteroid effects on wound healing, increased collagen synthesis is not a typical outcome. Corticosteroids are known to have catabolic effects on tissue, often leading to decreased collagen production rather than an increase. They inhibit fibroblast proliferation and reduce the deposition of collagen, which is vital for wound healing. On the other hand, delayed epithelialization, reduced inflammation, and impaired wound contraction are known side effects of corticosteroid use. Corticosteroids can slow down the inflammatory phase of healing, which is essential for progression to later stages of wound healing. By reducing inflammation, they can inadvertently prolong the time it takes for epithelialization to occur. Additionally, corticosteroids can negatively affect wound contraction by impairing the function of myofibroblasts, which play a critical role in pulling the edges of the wound together. Overall, the misunderstanding regarding increased collagen synthesis highlights a key aspect of how corticosteroids can adversely affect the wound healing process.